Journal of Pediatrics (2017) 43:8
Background: The mother’s immune status can be achieved by genetic and
breastfeeding impact descendants of the immune system. The study aimed to
determine whether a mother’s immune status and breastfeeding practices were
related to development of bronchiolitis in her infant.
frequency of T, B and natural kill (NK) cells in patients’ blood and their
mothers’ breast milk was determined using flow cytometry. The concentrations of
serum and breast milk IgG and IgD in individual patients and healthy control
were determined by enzyme-linked immunosorbent assay (ELISA). The relationships
between immunocytes, immunoglobulin and respiratory score (RS) were analyzed by
Spearman’s rank correlation test.
mothers of bronchiolitis patients had lower IgG concentrations in their breast
milk when compared to the mothers of healthy children. There was no significant
difference in the frequency of T cells, B cells, and NK cells in samples of
breast milk. However, significant decreases of CD3+, CD8+ T cells, as well as
significant increases of CD4+ T cells and CD19+ B cells were found in the serum
of bronchiolitis infants. There were positive correlation relationships between
RS and CD3+, CD4+ T cells, IgG and IgD concentrations.
Conclusion: Our data suggested that the mothers of bronchiolitis patients had
lower IgG concentration in their breast milk. The breast milk IgG might be
absorbed by the breastfeeding infants, which could play important role in
resistance of bronchiolitis.