Journal of Pediatrics (2017) 43:45
Background: To determine the efficacy and safety of early supplementation with 800
IU of vitamin D in very low birth weight (VLBW) infants.
infants with a birth weight less than 1500 g admitted to the Neonatal Intensive
Care Unit. Of these, 52 infants were eligible and received 800 IU/day vitamin D
from 2 weeks of age. We examined 25-hydroxyvitamin-D (25[OH]D) levels from cord
blood at birth and serum at 32 and 36 weeks of postmenstrual age.
Results: The study
infants were divided by cord-blood levels of 25(OH)D at birth into 25(OH)D
concentrations < 10 ng/mL (n = 20) or ≥ 10 ng/mL (n = 29). Vitamin D intake
of 800 IU/day safely achieved an 88% probability of vitamin D sufficiency at 36
weeks postmenstrual age in VLBW infants with cord-blood levels of 25(OH)D ≥ 10
ng/mL, and 65% probability of vitamin D sufficiency was observed in infants
with 25 OHD concentrations < 10 ng/mL at birth.
Conclusion: Considering the efficacy and safety of vitamin D supplementation in
this study, vitamin D intake of 800 IU/day may enhance vitamin D status during
early hospitalization in VLBW infants with 25 OHD concentrations <10 ng/mL
at birth. The clinical significance of optimal vitamin D intake in VLBW infants
needs to be studied in larger